

Olive ( Olea europaea L.) is a woody oil tree that comes from Mediterranean region. Over the past few years, a lot of attention was paid to obtaining biologically active compounds from natural sources. Since then, research discussing olive leaves’ potentialities increased.

In the middle of the previous century, olive leaf extract was found to be positively acting on hypertension. In the 1800s the British used them to handle tropical diseases such as malaria, which was so regnant in the colonies. In addition, later olive leaves became very popular folk remedy for fever. Ancient Egyptians used olive leaves for mummifying bodies of their pharaohs. Historically, olive leaves were used by old civilizations for the care of many illnesses. The significance of olive leaves as industrial and agricultural waste is emphasized by means of explaining their availability, therapeutic and nutritional effects, and research conducted on this field. Furthermore, it provides an overview of presence of enzymes. Additionally, it serves to highlight the role of olive leaf extract as an antioxidants and presents methods for determination of antioxidant potential. It also describes the vast range of information about methods for determination of antimicrobial potential focusing on effects on different microbes. This paper uses recent research findings with a wide range of study models to describe the antimicrobial potential of phenolic compounds. The present review reports on current knowledge of the most isolated phenolic compounds from olive leaf extract as well as methods for their isolation and characterization. Numerous publications on involving green technologies for isolation of active compounds from olive leaves have appeared over the past few decades. Olive leaf is studied as an important source of antimicrobials with low cost and used in medicine. Therefore, there are numerous recent papers about alternative solutions for inhibiting their influence on human health. Presently, the resistance of microorganisms to antibiotics is greater than ever. According to many reports, phenolic compounds isolated from olive leaves have very good biological activities, especially antimicrobial.
